TRS100 Quantitative Pharmaceutical Analysis System

Description

The TRS100 Quantitative Pharmaceutical Analysis System from Agilent Technologies is a transmission Raman spectroscopy (TRS) instrument configured for pharmaceutical quality control and development. Its primary function is the rapid, non-destructive analysis of intact tablets and capsules for content uniformity, assay, and polymorph screening. The system operates with an 830 nm Class 1 laser and acquires spectra across a range of 50 to 2300 cm⁻¹. A key advantage is the minimal sample preparation required; tablets and capsules can typically be analyzed without grinding, dissolution, or other processing. The technology can quantify active pharmaceutical ingredients (APIs) and excipients simultaneously, with reported limits of quantification as low as 0.1% by weight. It is designed for regulatory compliance, meeting the requirements of 21 CFR Part 11 and relevant USP and EP guidance. Applications include finished product testing, formulation development, and in-process control, with the goal of reducing analytical time and resource expenditure compared to traditional methods.