The MERSCOPE Platform
Manufacturer: Vizgen
Description
The MERSCOPE Platform is a spatial genomics instrument designed for high-plex, in situ analysis of biological samples. It utilizes Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH) technology, an imaging-based method that enables the detection and localization of hundreds to thousands of RNA transcripts directly within intact tissue sections. This approach allows researchers to map gene expression with spatial context across multiple scales, from whole tissue architecture down to subcellular resolution, facilitating single-cell analysis within its native microenvironment. The platform is automated for imaging workflows, aiming to generate comprehensive datasets that link cellular phenotype with precise genomic activity. Its primary application is in spatial biology for investigating complex tissue organization, cellular heterogeneity, and gene regulatory networks in fields such as neuroscience, oncology, and developmental biology.
Specifications
| Method | Multiplexed error-robust FISH (MERFISH) with automated image... |
| Scale | Whole tissue, single-cell, subcellular |