Nano Isothermal Titration Calorimeter

Description

Manufactured by TA Instruments – Waters LLC, the Nano Isothermal Titration Calorimeter is an instrument for studying molecular interactions in solution. It operates by measuring the heat released or absorbed during a binding event as one reagent is titrated into another at a constant temperature. The system functions within a temperature range of 2°C to 80°C. This technique provides direct measurement of binding affinity (equilibrium constant), enthalpy changes, and stoichiometry. The 'nano' designation suggests high sensitivity, enabling the study of interactions using minimal sample quantities. It is a key tool in biophysical chemistry, drug discovery, and life sciences for characterizing interactions between molecules such as proteins, nucleic acids, and small molecules.