LCMS-8065XE Triple Quadrupole LC/MS/MS Mass Spectrometer

Description

The Shimadzu LCMS-8065XE is a triple quadrupole liquid chromatography-tandem mass spectrometry (LC-MS/MS) system designed for high-sensitivity quantitative analysis. Its core architecture features molybdenum hyperbolic mass filters in both the first (Q1) and third (Q3) quadrupoles, with Q1 incorporating post-rods for enhanced performance. The system offers a resolution of less than 0.7 u FWHM, which is adjustable to 0.5 u. Standard ionization is provided by electrospray ionization (ESI), with atmospheric pressure chemical ionization (APCI) available as an option. A key technological foundation is Shimadzu's Ultra Fast Mass Spectrometry (UFMS) suite, which enables rapid polarity switching within 5 milliseconds without signal loss, MRM acquisition at rates up to 555 channels per second, and scanning speeds reaching 30,000 u/sec. The system incorporates specific advancements including StreamFocus Ionization Technology, which utilizes a low-dispersion nebulizer to improve ion intake efficiency and significantly reduce gas consumption. The Enhanced IonFocus unit employs a focusing electrode to guide ions while excluding neutral matrix components, contributing to analytical robustness. For fragmentation, the UFsweeper™ IV collision cell is designed with a larger inlet lens and an increased number of lenses to improve ion throughput and transmission. The instrument includes software features aimed at operational efficiency. Performance Concierge provides system monitoring and predictive maintenance alerts. Peakintelligence for LCMS applies algorithms to assist with peak detection, potentially reducing manual review time. The system is controlled via LabSolutions LCMS workstation software, with the LabSolutions Connect/Insight platform supporting workflow management, method creation, and result verification. In application, the LCMS-8065XE is used in environmental monitoring, food safety, pharmaceutical analysis, clinical research, and industrial quality control. It demonstrates particular utility in the analysis of per- and polyfluoroalkyl substances (PFAS), with reported detection limits at sub-ng/L levels for drinking water analysis via direct injection. Performance data indicates a sensitivity enhancement of 3 to 48 times over previous instrument generations, along with stability demonstrated by retaining over 85% of initial response after more than 10,000 consecutive injections of complex wastewater samples.