DynaPro Plate Reader 4 Dynamic Light Scattering Instrument
Manufacturer: Waters | Wyatt Technology
SKU: DynaPro Plate Reader 4
Description
The DynaPro Plate Reader 4 is a high-throughput dynamic light scattering (DLS) instrument configured for the automated screening of macromolecules and nanoparticles. It measures key parameters including hydrodynamic size, concentration, aggregation state, and sample stability. The system enables fully automated operation; after loading samples, measurements proceed without further user intervention. It is compatible with standard disposable well plates in 96, 384, or 1536-well formats. For integration into larger automated systems, the instrument can be connected to plate handlers and liquid-handling robots. Typical measurement times range from 5 to 60 seconds per well. Analysis is performed using an 830 nm laser, and the system can characterize particles within a size range of 0.5 nanometers to 1000 nanometers. The instrument's physical dimensions are 36 cm in width, 60 cm in depth, and 25 cm in height. This platform is well-suited for rapidly screening processing or formulation conditions, particularly in fields like biopharmaceutical development.
Specifications
| Item | DynaPro Plate Reader 4 Dynamic Light Scattering Instrument |
| Company | Waters | Wyatt Technology |
| Catalog Number | DynaPro Plate Reader 4 |
| Dimensions | (WxDxH) 36 x 60 x 25 cm |
| Quantity | EA |
| Type | Dynamic Light Scattering / Static Light Scattering |
| Particle Size | 0.5 to 1000 nm |
| Measuring Time | Measurement Time: 5 to 60 seconds per well830 nm |
| Plate Formats | 96, 384 or 1536 well plates |
| Sample Volume | 4 µL to 150 µL |
| Temperature Range | 4 °C to 85 °C |
| Measuring Range | 0.5 to 1000 nm (hydrodynamic radius); 1 to 1000 kDa (molecular weight). Particle concentration measurement is size-dependent. |
| Applications | Develop stable biopharmaceuticals, assess viral vector titer and aggregation, optimize protein buffers for crystallization, SAXS or chromatography, formulate theranostic nanoparticles, discover small-molecule and peptide inhibitors of protein-protein interactions |
| Wavelength(s) | 830 nm |
| Sensitivity | DLS: 0.125 mg/mL of lysozyme; SLS: 1 mg/mL of BSA |
| Detector(s) | Linearized avalanche photodiode for dynamic and static light scattering |
| Light Source | 830 nm, fiber-coupled diode laser |
| Sample Type | Proteins, polymers, and nanoparticles including viruses, liposomes, gene vectors, nanoemulsions, etc. |
| Interface | 162 mm high-resolution, color LCD multi-touch-screen display, and DYNAMICS® host software |