CellScape™ Precise Spatial Proteomics Platform

Description

The CellScape Precise Spatial Proteomics Platform from Bruker Spatial Biology is an integrated system for highly multiplexed protein analysis within intact tissue samples. It enables researchers to map the spatial distribution and co-expression of dozens of protein biomarkers simultaneously, preserving the native tissue architecture for context. The platform operates across scales, from whole tissue sections down to single-cell and subcellular resolution. The method is based on automated microfluidic immunofluorescence coupled with high-resolution confocal imaging. This cyclic process of staining and imaging allows for the quantitative analysis of protein expression patterns. The resulting data facilitates the investigation of cellular neighborhoods, functional states, and biomarker colocalization, which are critical for research in areas such as immuno-oncology, neuroscience, and developmental biology. The workflow is designed to be streamlined, from automated sample processing to data analysis and visualization. The platform provides tools for generating spatially resolved datasets that allow for the quantitative characterization of cell types, their protein signatures, and their spatial relationships within a tissue sample.