Aura CL System Particle Analyzers

Description

The Aura CL System from Waters | Wyatt Technology is an automated particle analyzer designed for characterizing subvisible particles in complex biological samples, particularly in cell therapy manufacturing. It addresses the challenge of distinguishing therapeutic cells from other particles like protein aggregates or harmful contaminants. The system utilizes two core technologies: Backgrounded Membrane Imaging (BMI) and Fluorescence Membrane Microscopy (FMM). It can measure particles with an equivalent circular diameter (ECD) ranging from greater than 1 µm to less than 5 mm. Measurement times are approximately one minute per sample for BMI and 30 seconds per sample for FMM across three fluorescence channels. Key capabilities include counting and identifying cell types, assessing cell viability, and detecting residual microcarriers like Dynabeads. The system requires only a small sample volume (5 µL) and can process a 96-well plate of 40-µL samples in under an hour, providing a high-throughput alternative to manual microscopy.