Acetonitrile with 0.1% Trifluoroacetic Acid (v/v), Optima LC/MS, Solvent Blends, Fisher Chemical

Description

This is an Optima LC/MS grade solvent blend designed for compatibility with mass spectrometry detection. It consists of acetonitrile modified with 0.1% trifluoroacetic acid (TFA) on a volume/volume basis. The product is supplied in a 2.5-liter amber glass bottle. The CAS number for the base acetonitrile solvent is 75-05-8. Trifluoroacetic acid is employed in LC/MS as a volatile ion-pairing agent and mobile phase additive, often useful for improving the separation and detection of basic compounds or peptides. The Optima grade signifies low levels of non-volatile residues and metals, which helps minimize signal suppression and background noise in the mass spectrometer, supporting more sensitive and reliable analyses.