α,β-Methylene-ATP trisodium

Description

α,β-Methylene-ATP trisodium is a biochemical reagent supplied by MedChemExpress under the catalog number HY-108652. This compound is a phosphonate analog of adenosine triphosphate (ATP), where the oxygen bridge between the α and β phosphates is replaced by a methylene group, rendering it resistant to hydrolysis by certain enzymes. Available in quantities of 5 mg, 10 mg, and 25 mg, it serves as a pharmacological tool in purinergic signaling research. Scientific literature identifies it as a ligand for P2X receptors, specifically acting as a highly selective agonist for the P2X1 and P2X3 receptor subtypes. It demonstrates negligible activity at other P2X receptors (P2X2, P2X4, P2X5, P2X6, P2X7), making it useful for selectively studying the function and physiology of P2X1 and P2X3 in various biological systems.